Purpose: Latanoprost is known to have several ocular side effects, including redness of the eyelids, lengthening of the eyelashes, an increase in iris pigmentation, and dryness of the eyes that causes discomfort. There are also several rarer systemic side effects reported in the literature, including chest pain. Case Report: Here we report a rare case of a patient who developed a cutaneous blistering rash on both eyelids, both sides of the neck, and the dorsum of both hands after direct contact with latanoprost eye drops. The lesions cleared following withdrawal of the eye drops. Conclusion: Topical latanoprost can cause severe blistering of the skin that could undermine a patient’ s confidence in the treating medical team. Reporting of an adverse effect is difficult when a generic topical medication is used.